Since her debut in 2008, IU has received over 200 award nominations, winning over 100 of them. She has won twenty-five Melon Music Awards, sixteen Gaon Chart Music Awards, five Korean Music Awards, fourteen Mnet Asian Music Awards, seven Seoul Music Awards, and eight Golden Disc Awards. IU has also won several awards for her work as an actress, earning the title "Best New Actress" at the 2014 KBS Drama Awards for her performance in You're the Best, Lee Soon-shin.

IU has received ten Daesang (grand prize) awards from various award shows, including five from the Melon Music Awards and three from the Golden Disc Awards. In 2012, she was named to the Forbes Korea Power Celebrity list as one of the most influential people in South Korea, and has since been mentioned five times. Additionally, IU was honored at the 2015 Korean Popular Culture and Arts Awards, held by the Korean Ministry of Culture, Sports and Tourism, for her influence and success in the music industry. In 2022, she was recipient of the Visionary Award, instituted by CJ ENM, which recognizes talents from the Korean film and television industry for their contributions to "leading trends and spearheading innovations.


● Best Couple Award ("You Are The Best!") - 2013 KBS Drama Awards - December 31, 2013
● Best New Actress ("You Are The Best!" & "Bel Ami) - 2013 KBS Drama Awards - December 31, 2013
● Best Couple Award ("Moon Lovers: Scarlet Heart Ryeo") - 2016 SBS Drama Awards - December 31, 2016
● Most Popular Actress - 2019 (55th) BaekSang Arts Awards - May 1, 2019
● Popularity Award - 2022 (43rd) Blue Dragon Film Awards - November 25, 2022
● Most Popular Actress - 2023 (59th) BaekSang Arts Awards - April 28, 2023
● Best Actress - 2025 (4th) Blue Dragon Series Awards - July 18, 2025 ▸Video
● Popular Star Award - 2025 (4th) Blue Dragon Series Awards - July 18, 2025 ▸Video